廖子嫻 老師
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廖子嫻 教授
研究領域：
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研究室：國研大樓1006-9室
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學歷：清華大學 化學工程學博士
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網站：
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學歷:
• 2013 Ph.D., Department of Chemical Engineering, National Tsing Hua University, Taiwan
• 2009 M.S., Department of Chemical Engineering, National Tsing Hua University, Taiwan
• 2007 B.S., Department of Agronomy, National Chung Hsing University, Taiwan
• 2023.02 – Present Professor, Institute of Medical Science and Technology, National Sun Yat-sen University, Taiwan
• 2018.02 – 2023.01 Associate professor, Institute of Medical Science and Technology, National Sun Yat-sen University, Taiwan
• 2014.08 – 2018.01 Assistant professor, Institute of Medical Science and Technology, National Sun Yat-sen University, Taiwan
• 2013.07 – 2014.07 Postdoctoral Fellow, Department of Chemical Engineering, National Tsing Hua University, Taiwan
• Utilizing Polymers for pH-Responsive Nano-Medicine Delivery Systems and Hydrogels: Spectral Analysis and Photo-Induced Hydrogel/Polymers
• Nano-Modified Virotherapy for Overcoming Resistance to EGFR-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer
• Virus-Mediated Cellular Engineering: Exploring Transduction for Enhanced Therapeutic Approaches
• Investigating Immune Responses within the Tumor Microenvironment
• 112 年度 國科會吳大猷先生紀念獎
• 112-114 年度 中山大學 聘年輕學者
• 112-114 年度 國科會生科處優秀年輕學者研究計畫
• 111-113 年度 國科會工程處優秀年輕學者研究計畫
• 108-111 年度 國科會生科處優秀年輕學者研究計畫
• 108-111 年度 國科會工程處優秀年輕學者研究計畫
• 108-112 年度 中山大學學術研究績優教師
• 109 年度 台綜大年輕學者創新獎 優等獎
• 107 年度 中山大學特聘年輕學者獎
• 106年度 中山大學年輕學者獎
• 105-107 年度 國科會工程處優秀年輕學者研究計畫
• 105-107 年度 國科會生科處優秀年輕學者研究計畫
• 111 年度 中山大學教學優優良課程-基礎奈米生醫材料與顯微影像技術
• 104-110 年度 中山大學教學優優良課程-基礎奈米生醫材料與藥物輸送
• 111 年度 中山大學教學優優良課程-書報討論(一)
• 105 年度 中山大學教學優優良課程-醫學科技導論
• 105 年度 中山大學理學院優良導師
• 103-105 年度 中山大學教師學術論文獎勵
• 103-105 年度 中山大學新進教師獎勵
• 112-114 年度 中山大學 聘年輕學者
• 112-114 年度 國科會生科處優秀年輕學者研究計畫
• 111-113 年度 國科會工程處優秀年輕學者研究計畫
• 108-111 年度 國科會生科處優秀年輕學者研究計畫
• 108-111 年度 國科會工程處優秀年輕學者研究計畫
• 108-112 年度 中山大學學術研究績優教師
• 109 年度 台綜大年輕學者創新獎 優等獎
• 107 年度 中山大學特聘年輕學者獎
• 106年度 中山大學年輕學者獎
• 105-107 年度 國科會工程處優秀年輕學者研究計畫
• 105-107 年度 國科會生科處優秀年輕學者研究計畫
• 111 年度 中山大學教學優優良課程-基礎奈米生醫材料與顯微影像技術
• 104-110 年度 中山大學教學優優良課程-基礎奈米生醫材料與藥物輸送
• 111 年度 中山大學教學優優良課程-書報討論(一)
• 105 年度 中山大學教學優優良課程-醫學科技導論
• 105 年度 中山大學理學院優良導師
• 103-105 年度 中山大學教師學術論文獎勵
• 103-105 年度 中山大學新進教師獎勵
• 生物材料
• 細胞分子生物學
• 組織工程
• 細胞分子生物學
• 組織工程
專利:
1. Pan-Chyr Yang, S.-Ja Tseng, Zi-Xian Liao. 光觸發病毒療法之遠端控制 中華民國專利 I722252.
2. Pan-Chyr Yang, S.-Ja Tseng, Zi-Xian Liao. “Remote Control Of Light-Triggered Virotherapy.” 日本專利 特願2019-523822
3. Pan-Chyr Yang, S.-Ja Tseng, Zi-Xian Liao. 光觸發病毒療法之遠端控制 中國專利 CN201780068030.8
4. Hsing-wen Sung, Chun-wen Hsiao, Chieh-cheng Huang, Min-fan Chung, Zi-xian Liao, Wei-lun Chiang. “Acid-substituted polyaniline-grafted hydrogel copolymer and use thereof.” US Patent No. 20,160,000,919.
5. Hsing-Wen Sung, Kiran Sonaje, Zi-Xian Liao, Ha Giang Thi Nguyen, Er-Yuan Chuang, Hosheng Tu. “Pharmaceutical composition of nanoparticles.” US Patent No.8361439.
6. Hsing-Wen Sung, Kiran Sonaje, Zi-Xian Liao, Ha Giang Thi Nguyen, Er-Yuan Chuang, Hosheng Tu. “Pharmaceutical composition of nanoparticles.” , US Patent No. 8354094.
7. Hsing-Wen Sung, Zi-Xian Liao, Ko-Jie Chen, Cherng-Jyh Ke, Hosheng Tu. “Pharmaceutical composition of nanoparticles.” , US Patent No. 8318200.
8. Hsing-Wen Sung, Zi-Xian Liao, Min-Fan Chung, Ko-Jie Chen, Hosheng Tu. “Pharmaceutical composition of nanoparticles.” , US Patent No. 8318198.
9.Hsing-Wen Sung, Ha Giang Thi Nguyen, Fang-Yi Su, Er-Yuan Chuang, Zi-Xian Liao, Hosheng Tu. “Pharmaceutical composition of nanoparticles.” , US Patent No. 8574544.
10.Hsing-Wen Sung, Zi-Xian Liao, Shu-Fen Peng, Hosheng Tu. “Nanoparticles for protein drug delivery.” , US Patent No. 8187570.
11.Hsing-Wen Sung, Zi-Xian Liao, Shu-Fen Peng, Hosheng Tu. “Nanoparticles for protein drug delivery.” , US Patent No. 8283317.
1. Pan-Chyr Yang, S.-Ja Tseng, Zi-Xian Liao. 光觸發病毒療法之遠端控制 中華民國專利 I722252.
2. Pan-Chyr Yang, S.-Ja Tseng, Zi-Xian Liao. “Remote Control Of Light-Triggered Virotherapy.” 日本專利 特願2019-523822
3. Pan-Chyr Yang, S.-Ja Tseng, Zi-Xian Liao. 光觸發病毒療法之遠端控制 中國專利 CN201780068030.8
4. Hsing-wen Sung, Chun-wen Hsiao, Chieh-cheng Huang, Min-fan Chung, Zi-xian Liao, Wei-lun Chiang. “Acid-substituted polyaniline-grafted hydrogel copolymer and use thereof.” US Patent No. 20,160,000,919.
5. Hsing-Wen Sung, Kiran Sonaje, Zi-Xian Liao, Ha Giang Thi Nguyen, Er-Yuan Chuang, Hosheng Tu. “Pharmaceutical composition of nanoparticles.” US Patent No.8361439.
6. Hsing-Wen Sung, Kiran Sonaje, Zi-Xian Liao, Ha Giang Thi Nguyen, Er-Yuan Chuang, Hosheng Tu. “Pharmaceutical composition of nanoparticles.” , US Patent No. 8354094.
7. Hsing-Wen Sung, Zi-Xian Liao, Ko-Jie Chen, Cherng-Jyh Ke, Hosheng Tu. “Pharmaceutical composition of nanoparticles.” , US Patent No. 8318200.
8. Hsing-Wen Sung, Zi-Xian Liao, Min-Fan Chung, Ko-Jie Chen, Hosheng Tu. “Pharmaceutical composition of nanoparticles.” , US Patent No. 8318198.
9.Hsing-Wen Sung, Ha Giang Thi Nguyen, Fang-Yi Su, Er-Yuan Chuang, Zi-Xian Liao, Hosheng Tu. “Pharmaceutical composition of nanoparticles.” , US Patent No. 8574544.
10.Hsing-Wen Sung, Zi-Xian Liao, Shu-Fen Peng, Hosheng Tu. “Nanoparticles for protein drug delivery.” , US Patent No. 8187570.
11.Hsing-Wen Sung, Zi-Xian Liao, Shu-Fen Peng, Hosheng Tu. “Nanoparticles for protein drug delivery.” , US Patent No. 8283317.
代表著作:
1. Liao, Z. X., Luo, Y.; Kempson, I. M.; Hsu, S. H.; Li, L. N.; Huang, P. H.; Tseng, S. J.*, Clinical strategy of antibody-drug conjugate as potential modification for virotherapy. Drug Discovery Today (Invited submitted:DRUDIS-D-23-00107). (IF: 7.4；Rank 23/278 in Pharmacology & Pharmacy)
2. Ou, D. L. #; Liao, Z. X.#, Kempson I. M.; Li L.; Yang, P. C.; Tseng, S. J.* , Nano-modified viruses prime the tumor microenvironment and promote the photodynamic virotherapy in liver cancer. Journal of Biomedical Science 2023, 250, 108521. (I.F:13.5; Rank: 7/278 in Pharmacology & Pharmacy；#co-first author)
3. Liao, Z. X., Kempson, I. M.; Hsu, S. H.; Luo, Y.; Tang, S. C.; Yang, P. C.; Tseng, S. J.*, Potential targeting tumor microenvironment to improve cancer virotherapy. Pharmacology & Therapeutics 2023, 250, 108521. (I.F:13.5; Rank: 7/278 in Pharmacology & Pharmacy)
4. Tseng S. J.* ; Kempson I. M.; Liao, Z. X.; Ho Y. C.; Yang, P. C.*, An acid degradable, lactate oxidizing nanoparticle formulation for non-small cell lung cancer virotherapy. Nano Today 2022, 46, 101582. (IF: 17.4, Rank 19/344 in Materials Science, Multidisciplinary)
5. Hsieh, C. C., Hsieh M. J., Wang Y. H., Liao, Z. X. *, Macrophage distribution affected by virus-encoded granulocyte macrophage colony stimulating factor combined with lactate oxidase. ACS Omega 2022, 7(27), 24020-24026. (IF: 4.1, Rank 69/178 in Chemistry, Multidisciplinary)
6. Liao, Z. X.; Kempson I. M.; Hsieh C. C.; Tseng S. J.*; Yang, P. C.*, Potential therapeutics using tumor-secreted lactate in nonsmall cell lung cancer. Drug Discovery Today 2021, 26 (11), 2508-2514. (I.F.: 7.4, Rank: 23/278 in Pharmacology & Pharmacy)
7. Ou, D. L.; Tseng, S. J.; Kempson, I. M.; Hsu, C. L.; Yang, P. C.; Liao, Z. X. *, Enhanced Targeting and Immune Activation of Tumor Microenvironment by Nanomodified Anti-PD1 in Liver Cancer. Advanced Therapeutics 2021, 2100048. (IF: 4.6, Rank 71/278 in Pharmacology & Pharmacy)
8. Lo, Y. L.; Huang X. S.; Chen, H. Y.; Huang Y. C.; Liao, Z. X.*; Wang, L. F.*, ROP and ATRP fabricated redox sensitive micelles based on PCL-SS-PMAA diblock copolymers to co-deliver PTX and CDDP for lung cancer therapy. Colloids and Surfaces B-Biointerfaces 2021, 198, 111443. (IF: 5.8, Rank 9/70 in Biophysics )
9. Liao Z. X.*, Ou D. L., Hsieh M. J., Hsieh C. C., Synergistic Effect of Repolarization of M2 to M1 Macrophages Induced by Iron Oxide Nanoparticles Combined with Lactate Oxidase. Int. J. Mol. Sci. 2021, 22(24), 13346 (IF: 5.6, Rank 66/285 in Biochemistry & Molecular Biology)
10. Lo, Y. L.; Tsai, M. F.; Soorni Y.; Hsu, C.; Liao, Z. X.; Wang, L. F.*, Dual Stimuli-Responsive Block Copolymers with Adjacent Redox- and Photo-Cleavable Linkages for Smart Drug Delivery. Biomacromolecules 2020, 21(8), 3342-3352. (IF: 6.2, Rank 3/52 in Chemistry, Organic )
11. Liao, Z. X.; Huang, K. Y.; Kempson, I. M.; Tseng S. J.; Yang, P. C.*, Nanomodified strategies to overcome EGFR-tyrosine kinase inhibitors resistance in non-small cell lung cancer. J Control Release 2020, 324, 482-492. (IF: 10.8, Rank 11/278 in Pharmacology & Pharmacy)
12. Liao, Z. X.; Fa, Y. C.; Kempson, I. M.; Tseng S. J.*, Repolarization of M2 to M1 macrophages triggered by lactate oxidase released from methylcellulose hydrogel. Bioconjugate Chem. 2019, 30 (10), 2697-2702. (IF: 4.7, Rank 8/52 in Chemistry, Organic)
13. Tseng, S. J.; Kempson I. M.; Huang, K. Y.; Li H. J.; Fa, Y. C.; Ho Y. C.; Liao, Z. X. *; Yang, P. C.*, Targeting Tumor Microenvironment by Bioreduction-Activated Nanoparticles for Light-Triggered Virotherapy. ACS Nano 2018, 12 (10), 9894-9902. (IF: 17.1, Rank 20/344 in Materials Science, Multidisciplinary)
14. Liao, Z. X.*; Kempson, I. M.*; Chen, M. J.; Fa, Y. C.; Huang, K. Y.; Wang, L. F.*, Micro-scale RNA interference using iron oxide nanoparticlemodified lentivirus. ChemNanoMat 2018, 4, 98-102. (IF: 3.8, Rank 78/178 in Chemistry, Multidisciplinary)
15. Liao, Z. X.*; Liu, M. C.; Kempson, I. M.; Fa, Y. C.; Huang, K. Y., Light-triggered methylcellulose gold nanoparticle hydrogels for leptin release to inhibit fat stores in adipocytes. Int J Nanomedicine 2017, 2017 (12), 7603-7611. (IF: 8.0, Rank 17/278 in Pharmacology & Pharmacy)
16. Liao, Z. X.*; Kempson, I. M.*; Fa, Y. C.; Liu, M. C.; Hsieh, L. C.; Huang, K. Y.; Wang, L. F.*, Magnetically guided viral transduction of gene-based sensitization for localized photodynamic therapy to overcome multidrug resistance in breast cancer cells. Bioconjug Chem. 2017, 28 (6), 1702-1708. (IF: 4.7, Rank 8/52 in Chemistry, Organic)
17. Yang, C. L.; Chen, J. P.; Wei, K. C.; Chen, J. Y.; Huang, C. W.; Liao, Z. X.*, Release of doxorubicin by a folate-grafted, chitosan-coated magnetic nanoparticle. Nanomaterials 2017, 7 (4), 85. (IF: 5.3, Rank 39/160 in Physics, Applied)
18. Tseng, S. J.; Huang, K. Y.; Kempson, I. M.; Kao, S. H.; Liu, M. C.; Yang, S. C.; Liao, Z. X.*; Yang, P. C.*, Remote control of light-triggered virotherapy. ACS Nano 2016, 10 (11), 10339-10346. (IF: 17.1, Rank 20/344 in Materials Science, Multidisciplinary)
19. Tseng, S. J.#; Liao, Z. X.#; Kao, S. H.; Zeng, Y. F.; Huang, K. Y.; Li, H. J.; Yang, C. L.; Deng, Y. F.; Huang, C. F.; Yang, S. C.; Yang, P. C.; Kempson, I. M. (#Both authors contributed equally to this work), Highly specific in vivo gene delivery for p53-mediated apoptosis and genetic photodynamic therapies of tumour. Nat Commun 2015, 6, 6456. (IF: 16.6, Rank 6/73 in Multidisciplinary Science)
20. Huang, C. C.#; Liao, Z. X.#; Lu, H. M.; Pan, W. Y.; Wan, W. L.; Chen, C. C.; Sung, H. W.* (#Both authors contributed equally to this work), Cellular organelle-dependent cytotoxicity of iron oxide nanoparticles and its implications for cancer diagnosis and treatment: a mechanistic investigation. Chem Mater 2016, 28 (24), 9017-9025. (IF: 8.6, Rank 63/344 in Materials Science, Multidisciplinary)
21. Lo, Y. L.; Chou, H. L.; Liao, Z. X.; Huang, S. J.; Ke, J. H.; Liu, Y. S.; Chiu, C. C.; Wang, L. F., Chondroitin sulfate-polyethylenimine copolymer-coated superparamagnetic iron oxide nanoparticles as an efficient magneto-gene carrier for microRNA-encoding plasmid DNA delivery. Nanoscale 2015, 7 (18), 8554-65. (IF: 6.7, Rank 27/160 in Physics, Applied)
22. Liao, Z. X.#; Chuang, E. Y.#; Lin, C. C.; Ho, Y. C.; Lin, K. J.; Cheng, P. Y.; Chen, K. J.; Wei, H. J.; Sung, H. W. (#Both authors contributed equally to this work), An AS1411 aptamer-conjugated liposomal system containing a bubble-generating agent for tumor-specific chemotherapy that overcomes multidrug resistance. J Control Release 2015, 208, 42-51. (IF: 10.8, Rank 11/278 in Pharmacology & Pharmacy)
23. Kao, S. H.; Huang, K. Y.; Li, H. J.; Tseng, S. J.; Liao, Z. X.; Kempson, I. M., Environmental pH-sensitive polymeric nano-carriers for targeted tumor delivery. J Control Release 2015, 213, e46-7. (IF: 10.8, Rank 11/278 in Pharmacology & Pharmacy)
24. Hsiao, C. W., Chen, H. L., Liao, Z. X., Sureshbabu, R.,; Hsiao, H. C.; Lin, S.-J.; Chang, Y.; Sung, H. W., Effective photothermal killing of pathogenic bacteria by using spatially tunable colloidal gels with nano-localized heating sources. Advanced Functional Materials 2015, 25, 721-728. (IF: 19.0, Rank 8/178 in Chemistry, Multidisciplinary)
25. Hsiao, C. W.; Chuang, E. Y.; Chen, H. L.; Wan, D.; Korupalli, C.; Liao, Z. X.; Chiu, Y. L.; Chia, W. T.; Lin, K. J.; Sung, H. W., Photothermal tumor ablation in mice with repeated therapy sessions using NIR-absorbing micellar hydrogels formed in situ. Biomaterials 2015, 56, 26-35. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
26. Pu, H. L.; Chiang, W. L.; Maiti, B.; Liao, Z. X.; Ho, Y. C.; Shim, M. S.; Chuang, E. Y.; Xia, Y.; Sung, H. W., Nanoparticles with dual responses to oxidative stress and reduced ph for drug release and anti-inflammatory applications. ACS Nano 2014, 8 (2), 1213-21. (IF: 17.1, Rank 20/344 in Materials Science, Multidisciplinary)
27. Liao, Z. X.; Peng, S. F.; Chiu, Y. L.; Hsiao, C. W.; Liu, H. Y.; Lim, W. H.; Lu, H. M.; Sung, H. W.*, Enhancement of efficiency of chitosan-based complexes for gene transfection with poly(gamma-glutamic acid) by augmenting their cellular uptake and intracellular unpackage. J Control Release 2014, 193, 304-15. (IF: 10.8, Rank 11/278 in Pharmacology & Pharmacy)
28. Liao, Z. X.; Li, Y. C.; Lu, H. M.; Sung, H. W.*, A genetically-encoded KillerRed protein as an intrinsically generated photosensitizer for photodynamic therapy. Biomaterials 2014, 35 (1), 500-8. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
29. Liao, Z. X.; Chuang, E. Y.; Hsiao, C. W.; Sung, H. W.*, 21. pH-sensitive chitosan-based nanoparticles for protein drug delivery: oral approaches: Original research article: a novel pH-sensitive hydrogel composed of carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery, 2004. J Control Release 2014, 190, 68-70. (IF: 10.8, Rank 11/278 in Pharmacology & Pharmacy)
30. Huang, C. C.; Liao, Z. X.; Chen, D. Y.; Hsiao, C. W.; Chang, Y.; Sung, H. W.*, Injectable cell constructs fabricated via culture on a thermoresponsive methylcellulose hydrogel system for the treatment of ischemic diseases. Adv Healthc Mater 2014, 3 (8), 1133-48. (IF: 10.0, Rank 8/96 in Engineering, Biomedical)
31. Liao, Z. X.; Hsiao, C. W.; Ho, Y. C.; Chen, H. L.; Sung, H. W.*, Disulfide bond-conjugated dual PEGylated siRNAs for prolonged multiple gene silencing. Biomaterials 2013, 34 (28), 6930-7. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
32. Ke, C. J.; Chiang, W. L.; Liao, Z. X.; Chen, H. L.; Lai, P. S.; Sun, J. S.; Sung, H. W.*, Real-time visualization of pH-responsive PLGA hollow particles containing a gas-generating agent targeted for acidic organelles for overcoming multi-drug resistance. Biomaterials 2013, 34 (1), 1-10. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
33. Hsiao, C. W.; Bai, M. Y.; Chang, Y.; Chung, M. F.; Lee, T. Y.; Wu, C. T.; Maiti, B.; Liao, Z. X.; Li, R. K.; Sung, H. W.*, Electrical coupling of isolated cardiomyocyte clusters grown on aligned conductive nanofibrous meshes for their synchronized beating. Biomaterials 2013, 34 (4), 1063-72. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
34. Chen, M. C.; Mi, F. L.; Liao, Z. X.; Hsiao, C. W.; Sonaje, K.; Chung, M. F.; Hsu, L. W.; Sung, H. W., Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules. Adv Drug Deliv Rev 2013, 65 (6), 865-79. (IF: 16.1, Rank 4/278 in Pharmacology & Pharmacy)
35. Sung, H. W.; Sonaje, K.; Liao, Z. X.; Hsu, L. W.; Chuang, E. Y., pH-responsive nanoparticles shelled with chitosan for oral delivery of insulin: from mechanism to therapeutic applications. Acc Chem Res 2012, 45 (4), 619-29. (IF: 18.3, Rank 9/178 in Chemistry, Multidisciplinary)
36. Liao, Z. X.; Peng, S. F.; Ho, Y. C.; Mi, F. L.; Maiti, B.; Sung, H. W.*, Mechanistic study of transfection of chitosan/DNA complexes coated by anionic poly(gamma-glutamic acid). Biomaterials 2012, 33 (11), 3306-15. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
37. Chung, M. F.; Chen, K. J.; Liang, H. F.; Liao, Z. X.; Chia, W. T.; Xia, Y.*; Sung, H. W.*, A liposomal system capable of generating CO2 bubbles to induce transient cavitation, lysosomal rupturing, and cell necrosis. Angew Chem Int Ed Engl 2012, 51 (40), 10089-93. (IF: 16.6, Rank 13/178 in Chemistry, Multidisciplinary)
38. Chiang, W. L.; Ke, C. J.; Liao, Z. X.; Chen, S. Y.; Chen, F. R.; Tsai, C. Y.; Xia, Y.*; Sung, H. W.*, Pulsatile drug release from PLGA hollow microspheres by controlling the permeability of their walls with a magnetic field. Small 2012, 8 (23), 3584-8. (IF: 13.3, Rank 11/160 in Physics, Applied)
39. Peng, S. F.; Tseng, M. T.; Ho, Y. C.; Wei, M. C.; Liao, Z. X.; Sung, H. W.*, Mechanisms of cellular uptake and intracellular trafficking with chitosan/DNA/poly(gamma-glutamic acid) complexes as a gene delivery vector. Biomaterials 2011, 32 (1), 239-48. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
40. Peng, S. F.; Su, C. J.; Wei, M. C.; Chen, C. Y.; Liao, Z. X.; Lee, P. W.; Chen, H. L.; Sung, H. W.*, Effects of the nanostructure of dendrimer/DNA complexes on their endocytosis and gene expression. Biomaterials 2010, 31 (21), 5660-70. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
41. Liao, Z. X.; Ho, Y. C.; Chen, H. L.; Peng, S. F.; Hsiao, C. W.; Sung, H. W.*, Enhancement of efficiencies of the cellular uptake and gene silencing of chitosan/siRNA complexes via the inclusion of a negatively charged poly(gamma-glutamic acid). Biomaterials 2010, 31 (33), 8780-8. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
42. Lee, P. W.; Hsu, S. H.; Tsai, J. S.; Chen, F. R.; Huang, P. J.; Ke, C. J.; Liao, Z. X.; Hsiao, C. W.; Lin, H. J.; Sung, H. W.*, Multifunctional core-shell polymeric nanoparticles for transdermal DNA delivery and epidermal Langerhans cells tracking. Biomaterials 2010, 31 (8), 2425-34. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
1. Liao, Z. X., Luo, Y.; Kempson, I. M.; Hsu, S. H.; Li, L. N.; Huang, P. H.; Tseng, S. J.*, Clinical strategy of antibody-drug conjugate as potential modification for virotherapy. Drug Discovery Today (Invited submitted:DRUDIS-D-23-00107). (IF: 7.4；Rank 23/278 in Pharmacology & Pharmacy)
2. Ou, D. L. #; Liao, Z. X.#, Kempson I. M.; Li L.; Yang, P. C.; Tseng, S. J.* , Nano-modified viruses prime the tumor microenvironment and promote the photodynamic virotherapy in liver cancer. Journal of Biomedical Science 2023, 250, 108521. (I.F:13.5; Rank: 7/278 in Pharmacology & Pharmacy；#co-first author)
3. Liao, Z. X., Kempson, I. M.; Hsu, S. H.; Luo, Y.; Tang, S. C.; Yang, P. C.; Tseng, S. J.*, Potential targeting tumor microenvironment to improve cancer virotherapy. Pharmacology & Therapeutics 2023, 250, 108521. (I.F:13.5; Rank: 7/278 in Pharmacology & Pharmacy)
4. Tseng S. J.* ; Kempson I. M.; Liao, Z. X.; Ho Y. C.; Yang, P. C.*, An acid degradable, lactate oxidizing nanoparticle formulation for non-small cell lung cancer virotherapy. Nano Today 2022, 46, 101582. (IF: 17.4, Rank 19/344 in Materials Science, Multidisciplinary)
5. Hsieh, C. C., Hsieh M. J., Wang Y. H., Liao, Z. X. *, Macrophage distribution affected by virus-encoded granulocyte macrophage colony stimulating factor combined with lactate oxidase. ACS Omega 2022, 7(27), 24020-24026. (IF: 4.1, Rank 69/178 in Chemistry, Multidisciplinary)
6. Liao, Z. X.; Kempson I. M.; Hsieh C. C.; Tseng S. J.*; Yang, P. C.*, Potential therapeutics using tumor-secreted lactate in nonsmall cell lung cancer. Drug Discovery Today 2021, 26 (11), 2508-2514. (I.F.: 7.4, Rank: 23/278 in Pharmacology & Pharmacy)
7. Ou, D. L.; Tseng, S. J.; Kempson, I. M.; Hsu, C. L.; Yang, P. C.; Liao, Z. X. *, Enhanced Targeting and Immune Activation of Tumor Microenvironment by Nanomodified Anti-PD1 in Liver Cancer. Advanced Therapeutics 2021, 2100048. (IF: 4.6, Rank 71/278 in Pharmacology & Pharmacy)
8. Lo, Y. L.; Huang X. S.; Chen, H. Y.; Huang Y. C.; Liao, Z. X.*; Wang, L. F.*, ROP and ATRP fabricated redox sensitive micelles based on PCL-SS-PMAA diblock copolymers to co-deliver PTX and CDDP for lung cancer therapy. Colloids and Surfaces B-Biointerfaces 2021, 198, 111443. (IF: 5.8, Rank 9/70 in Biophysics )
9. Liao Z. X.*, Ou D. L., Hsieh M. J., Hsieh C. C., Synergistic Effect of Repolarization of M2 to M1 Macrophages Induced by Iron Oxide Nanoparticles Combined with Lactate Oxidase. Int. J. Mol. Sci. 2021, 22(24), 13346 (IF: 5.6, Rank 66/285 in Biochemistry & Molecular Biology)
10. Lo, Y. L.; Tsai, M. F.; Soorni Y.; Hsu, C.; Liao, Z. X.; Wang, L. F.*, Dual Stimuli-Responsive Block Copolymers with Adjacent Redox- and Photo-Cleavable Linkages for Smart Drug Delivery. Biomacromolecules 2020, 21(8), 3342-3352. (IF: 6.2, Rank 3/52 in Chemistry, Organic )
11. Liao, Z. X.; Huang, K. Y.; Kempson, I. M.; Tseng S. J.; Yang, P. C.*, Nanomodified strategies to overcome EGFR-tyrosine kinase inhibitors resistance in non-small cell lung cancer. J Control Release 2020, 324, 482-492. (IF: 10.8, Rank 11/278 in Pharmacology & Pharmacy)
12. Liao, Z. X.; Fa, Y. C.; Kempson, I. M.; Tseng S. J.*, Repolarization of M2 to M1 macrophages triggered by lactate oxidase released from methylcellulose hydrogel. Bioconjugate Chem. 2019, 30 (10), 2697-2702. (IF: 4.7, Rank 8/52 in Chemistry, Organic)
13. Tseng, S. J.; Kempson I. M.; Huang, K. Y.; Li H. J.; Fa, Y. C.; Ho Y. C.; Liao, Z. X. *; Yang, P. C.*, Targeting Tumor Microenvironment by Bioreduction-Activated Nanoparticles for Light-Triggered Virotherapy. ACS Nano 2018, 12 (10), 9894-9902. (IF: 17.1, Rank 20/344 in Materials Science, Multidisciplinary)
14. Liao, Z. X.*; Kempson, I. M.*; Chen, M. J.; Fa, Y. C.; Huang, K. Y.; Wang, L. F.*, Micro-scale RNA interference using iron oxide nanoparticlemodified lentivirus. ChemNanoMat 2018, 4, 98-102. (IF: 3.8, Rank 78/178 in Chemistry, Multidisciplinary)
15. Liao, Z. X.*; Liu, M. C.; Kempson, I. M.; Fa, Y. C.; Huang, K. Y., Light-triggered methylcellulose gold nanoparticle hydrogels for leptin release to inhibit fat stores in adipocytes. Int J Nanomedicine 2017, 2017 (12), 7603-7611. (IF: 8.0, Rank 17/278 in Pharmacology & Pharmacy)
16. Liao, Z. X.*; Kempson, I. M.*; Fa, Y. C.; Liu, M. C.; Hsieh, L. C.; Huang, K. Y.; Wang, L. F.*, Magnetically guided viral transduction of gene-based sensitization for localized photodynamic therapy to overcome multidrug resistance in breast cancer cells. Bioconjug Chem. 2017, 28 (6), 1702-1708. (IF: 4.7, Rank 8/52 in Chemistry, Organic)
17. Yang, C. L.; Chen, J. P.; Wei, K. C.; Chen, J. Y.; Huang, C. W.; Liao, Z. X.*, Release of doxorubicin by a folate-grafted, chitosan-coated magnetic nanoparticle. Nanomaterials 2017, 7 (4), 85. (IF: 5.3, Rank 39/160 in Physics, Applied)
18. Tseng, S. J.; Huang, K. Y.; Kempson, I. M.; Kao, S. H.; Liu, M. C.; Yang, S. C.; Liao, Z. X.*; Yang, P. C.*, Remote control of light-triggered virotherapy. ACS Nano 2016, 10 (11), 10339-10346. (IF: 17.1, Rank 20/344 in Materials Science, Multidisciplinary)
19. Tseng, S. J.#; Liao, Z. X.#; Kao, S. H.; Zeng, Y. F.; Huang, K. Y.; Li, H. J.; Yang, C. L.; Deng, Y. F.; Huang, C. F.; Yang, S. C.; Yang, P. C.; Kempson, I. M. (#Both authors contributed equally to this work), Highly specific in vivo gene delivery for p53-mediated apoptosis and genetic photodynamic therapies of tumour. Nat Commun 2015, 6, 6456. (IF: 16.6, Rank 6/73 in Multidisciplinary Science)
20. Huang, C. C.#; Liao, Z. X.#; Lu, H. M.; Pan, W. Y.; Wan, W. L.; Chen, C. C.; Sung, H. W.* (#Both authors contributed equally to this work), Cellular organelle-dependent cytotoxicity of iron oxide nanoparticles and its implications for cancer diagnosis and treatment: a mechanistic investigation. Chem Mater 2016, 28 (24), 9017-9025. (IF: 8.6, Rank 63/344 in Materials Science, Multidisciplinary)
21. Lo, Y. L.; Chou, H. L.; Liao, Z. X.; Huang, S. J.; Ke, J. H.; Liu, Y. S.; Chiu, C. C.; Wang, L. F., Chondroitin sulfate-polyethylenimine copolymer-coated superparamagnetic iron oxide nanoparticles as an efficient magneto-gene carrier for microRNA-encoding plasmid DNA delivery. Nanoscale 2015, 7 (18), 8554-65. (IF: 6.7, Rank 27/160 in Physics, Applied)
22. Liao, Z. X.#; Chuang, E. Y.#; Lin, C. C.; Ho, Y. C.; Lin, K. J.; Cheng, P. Y.; Chen, K. J.; Wei, H. J.; Sung, H. W. (#Both authors contributed equally to this work), An AS1411 aptamer-conjugated liposomal system containing a bubble-generating agent for tumor-specific chemotherapy that overcomes multidrug resistance. J Control Release 2015, 208, 42-51. (IF: 10.8, Rank 11/278 in Pharmacology & Pharmacy)
23. Kao, S. H.; Huang, K. Y.; Li, H. J.; Tseng, S. J.; Liao, Z. X.; Kempson, I. M., Environmental pH-sensitive polymeric nano-carriers for targeted tumor delivery. J Control Release 2015, 213, e46-7. (IF: 10.8, Rank 11/278 in Pharmacology & Pharmacy)
24. Hsiao, C. W., Chen, H. L., Liao, Z. X., Sureshbabu, R.,; Hsiao, H. C.; Lin, S.-J.; Chang, Y.; Sung, H. W., Effective photothermal killing of pathogenic bacteria by using spatially tunable colloidal gels with nano-localized heating sources. Advanced Functional Materials 2015, 25, 721-728. (IF: 19.0, Rank 8/178 in Chemistry, Multidisciplinary)
25. Hsiao, C. W.; Chuang, E. Y.; Chen, H. L.; Wan, D.; Korupalli, C.; Liao, Z. X.; Chiu, Y. L.; Chia, W. T.; Lin, K. J.; Sung, H. W., Photothermal tumor ablation in mice with repeated therapy sessions using NIR-absorbing micellar hydrogels formed in situ. Biomaterials 2015, 56, 26-35. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
26. Pu, H. L.; Chiang, W. L.; Maiti, B.; Liao, Z. X.; Ho, Y. C.; Shim, M. S.; Chuang, E. Y.; Xia, Y.; Sung, H. W., Nanoparticles with dual responses to oxidative stress and reduced ph for drug release and anti-inflammatory applications. ACS Nano 2014, 8 (2), 1213-21. (IF: 17.1, Rank 20/344 in Materials Science, Multidisciplinary)
27. Liao, Z. X.; Peng, S. F.; Chiu, Y. L.; Hsiao, C. W.; Liu, H. Y.; Lim, W. H.; Lu, H. M.; Sung, H. W.*, Enhancement of efficiency of chitosan-based complexes for gene transfection with poly(gamma-glutamic acid) by augmenting their cellular uptake and intracellular unpackage. J Control Release 2014, 193, 304-15. (IF: 10.8, Rank 11/278 in Pharmacology & Pharmacy)
28. Liao, Z. X.; Li, Y. C.; Lu, H. M.; Sung, H. W.*, A genetically-encoded KillerRed protein as an intrinsically generated photosensitizer for photodynamic therapy. Biomaterials 2014, 35 (1), 500-8. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
29. Liao, Z. X.; Chuang, E. Y.; Hsiao, C. W.; Sung, H. W.*, 21. pH-sensitive chitosan-based nanoparticles for protein drug delivery: oral approaches: Original research article: a novel pH-sensitive hydrogel composed of carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery, 2004. J Control Release 2014, 190, 68-70. (IF: 10.8, Rank 11/278 in Pharmacology & Pharmacy)
30. Huang, C. C.; Liao, Z. X.; Chen, D. Y.; Hsiao, C. W.; Chang, Y.; Sung, H. W.*, Injectable cell constructs fabricated via culture on a thermoresponsive methylcellulose hydrogel system for the treatment of ischemic diseases. Adv Healthc Mater 2014, 3 (8), 1133-48. (IF: 10.0, Rank 8/96 in Engineering, Biomedical)
31. Liao, Z. X.; Hsiao, C. W.; Ho, Y. C.; Chen, H. L.; Sung, H. W.*, Disulfide bond-conjugated dual PEGylated siRNAs for prolonged multiple gene silencing. Biomaterials 2013, 34 (28), 6930-7. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
32. Ke, C. J.; Chiang, W. L.; Liao, Z. X.; Chen, H. L.; Lai, P. S.; Sun, J. S.; Sung, H. W.*, Real-time visualization of pH-responsive PLGA hollow particles containing a gas-generating agent targeted for acidic organelles for overcoming multi-drug resistance. Biomaterials 2013, 34 (1), 1-10. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
33. Hsiao, C. W.; Bai, M. Y.; Chang, Y.; Chung, M. F.; Lee, T. Y.; Wu, C. T.; Maiti, B.; Liao, Z. X.; Li, R. K.; Sung, H. W.*, Electrical coupling of isolated cardiomyocyte clusters grown on aligned conductive nanofibrous meshes for their synchronized beating. Biomaterials 2013, 34 (4), 1063-72. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
34. Chen, M. C.; Mi, F. L.; Liao, Z. X.; Hsiao, C. W.; Sonaje, K.; Chung, M. F.; Hsu, L. W.; Sung, H. W., Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules. Adv Drug Deliv Rev 2013, 65 (6), 865-79. (IF: 16.1, Rank 4/278 in Pharmacology & Pharmacy)
35. Sung, H. W.; Sonaje, K.; Liao, Z. X.; Hsu, L. W.; Chuang, E. Y., pH-responsive nanoparticles shelled with chitosan for oral delivery of insulin: from mechanism to therapeutic applications. Acc Chem Res 2012, 45 (4), 619-29. (IF: 18.3, Rank 9/178 in Chemistry, Multidisciplinary)
36. Liao, Z. X.; Peng, S. F.; Ho, Y. C.; Mi, F. L.; Maiti, B.; Sung, H. W.*, Mechanistic study of transfection of chitosan/DNA complexes coated by anionic poly(gamma-glutamic acid). Biomaterials 2012, 33 (11), 3306-15. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
37. Chung, M. F.; Chen, K. J.; Liang, H. F.; Liao, Z. X.; Chia, W. T.; Xia, Y.*; Sung, H. W.*, A liposomal system capable of generating CO2 bubbles to induce transient cavitation, lysosomal rupturing, and cell necrosis. Angew Chem Int Ed Engl 2012, 51 (40), 10089-93. (IF: 16.6, Rank 13/178 in Chemistry, Multidisciplinary)
38. Chiang, W. L.; Ke, C. J.; Liao, Z. X.; Chen, S. Y.; Chen, F. R.; Tsai, C. Y.; Xia, Y.*; Sung, H. W.*, Pulsatile drug release from PLGA hollow microspheres by controlling the permeability of their walls with a magnetic field. Small 2012, 8 (23), 3584-8. (IF: 13.3, Rank 11/160 in Physics, Applied)
39. Peng, S. F.; Tseng, M. T.; Ho, Y. C.; Wei, M. C.; Liao, Z. X.; Sung, H. W.*, Mechanisms of cellular uptake and intracellular trafficking with chitosan/DNA/poly(gamma-glutamic acid) complexes as a gene delivery vector. Biomaterials 2011, 32 (1), 239-48. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
40. Peng, S. F.; Su, C. J.; Wei, M. C.; Chen, C. Y.; Liao, Z. X.; Lee, P. W.; Chen, H. L.; Sung, H. W.*, Effects of the nanostructure of dendrimer/DNA complexes on their endocytosis and gene expression. Biomaterials 2010, 31 (21), 5660-70. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
41. Liao, Z. X.; Ho, Y. C.; Chen, H. L.; Peng, S. F.; Hsiao, C. W.; Sung, H. W.*, Enhancement of efficiencies of the cellular uptake and gene silencing of chitosan/siRNA complexes via the inclusion of a negatively charged poly(gamma-glutamic acid). Biomaterials 2010, 31 (33), 8780-8. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
42. Lee, P. W.; Hsu, S. H.; Tsai, J. S.; Chen, F. R.; Huang, P. J.; Ke, C. J.; Liao, Z. X.; Hsiao, C. W.; Lin, H. J.; Sung, H. W.*, Multifunctional core-shell polymeric nanoparticles for transdermal DNA delivery and epidermal Langerhans cells tracking. Biomaterials 2010, 31 (8), 2425-34. (IF: 14.0, Rank 4/96 in Engineering, Biomedical)
國科會計畫:
• 透過腫瘤微環境降解式水膠包覆奈米鐵與免疫型病毒來改善抗腫瘤巨噬細胞之極化並應用於原位癌 (112-2628-B-110 -004 -MY3)
• 透過編碼有PD-L1-shRNA之奈米修飾性病毒來改善腫瘤微環境的免疫活性並應用於非小細胞肺癌中 (111-2628-E-110 -007 -MY3)
• 光觸發性之遙控式病毒療法應於腦部膠質母細胞瘤之治療(3/3)(110-2628-B-110 -003)
• 光觸發性之遙控式病毒療法應於腦部膠質母細胞瘤之治療(2/3)(109-2628-B-110 -003)
• 光觸發性之遙控式病毒療法應於腦部膠質母細胞瘤之治療(1/3)(108-2628-B-110 -001)
• 藉由乳酸活化缺氧應答型載體微粒開啟病毒核糖核酸干擾現象並調節免疫治療中的腫瘤相關巨噬細胞(108-2628-E-110 -003 -MY3)
• 結合調控腫瘤微環境誘發自體抗腫瘤免疫反應與多功能聚合式siRNA於提升腫瘤治療效率之應用研究(105-2628-E-110 -001 -MY3)
• 透過可控制性第二型腺相關病毒之微米尺寸感染於腫瘤治療上之應用(105-2628-B-110 -004 -MY3)
• 高度專一性酸敏感載體於光動力治療誘導細胞走向凋亡之傳遞系統於腫瘤治療上的應用研究(103-2320-B-110 -005 -MY2)
• 透過腫瘤微環境降解式水膠包覆奈米鐵與免疫型病毒來改善抗腫瘤巨噬細胞之極化並應用於原位癌 (112-2628-B-110 -004 -MY3)
• 透過編碼有PD-L1-shRNA之奈米修飾性病毒來改善腫瘤微環境的免疫活性並應用於非小細胞肺癌中 (111-2628-E-110 -007 -MY3)
• 光觸發性之遙控式病毒療法應於腦部膠質母細胞瘤之治療(3/3)(110-2628-B-110 -003)
• 光觸發性之遙控式病毒療法應於腦部膠質母細胞瘤之治療(2/3)(109-2628-B-110 -003)
• 光觸發性之遙控式病毒療法應於腦部膠質母細胞瘤之治療(1/3)(108-2628-B-110 -001)
• 藉由乳酸活化缺氧應答型載體微粒開啟病毒核糖核酸干擾現象並調節免疫治療中的腫瘤相關巨噬細胞(108-2628-E-110 -003 -MY3)
• 結合調控腫瘤微環境誘發自體抗腫瘤免疫反應與多功能聚合式siRNA於提升腫瘤治療效率之應用研究(105-2628-E-110 -001 -MY3)
• 透過可控制性第二型腺相關病毒之微米尺寸感染於腫瘤治療上之應用(105-2628-B-110 -004 -MY3)
• 高度專一性酸敏感載體於光動力治療誘導細胞走向凋亡之傳遞系統於腫瘤治療上的應用研究(103-2320-B-110 -005 -MY2)
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